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Prenatal screening test

Non-invasive NIPT / NIPS

ihope, one of the most advanced prenatal screening tests, can detect fetal aneuploidies at very early time. Only 5ml blood from mother is required to detect trisomy 21, 18, and 13. Without invasive operations, this means safety for both mother and child.

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Prenatal screening report Non invasive 20th September 2017 Trisomy 21 (T21) Trisomy 18 (T18) Trisomy 13 (T13) Mono X (45, X) Not detected Not detected Not detected Not detected Conclusion Chromosome abnormality hasn't been detected.

Chromosome abnormality

Humans have 23 pairs or, in total, 46 chromosomes. Trisomy is one type of chromosome abnormalities where three copies of a particular chromosome are present instead of a pair.

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 21 20 22 23 x y

Abnormality of chromosome 21, 18, 13, and 23 (sex chromosome) results in Down, Edwards, Patau, and Turner syndrome which would affect conditions and development of fetuses.

ihope is a non-invasive prenatal test (NIPT or NIPS) which can detect Down, Edwards, Patau,... syndrome. It is strongly recommended to mothers who have high-risk results of Double test or Triple test before considering invasive diagnostics.

  • Safety

    ihope analyzes fetal DNA circulating freely in the maternal blood stream to detect chromosome abnormality of fetus without invasive techniques (amniocentesis, chorionic villus sampling). Consequently, safety of mothers and children are assured.

  • Reliability

    ihope applies Next Generation Sequencing (NGS) techniques to maximize accuracy to 99.9% and minimize false results to less than 1% in comparison with other conventional tests such as Double test or Triple test.

  • At ease

    ihope can be carried out from 9th week of pregnancy and only requires 5 ml maternal blood to perform the test. Reports are available after 5 working days.

ihope test

  • Detects Down, Edwards, Patau,… syndrome
  • Safe for both mother and fetus
  • Sensitivity up to 99.9%
  • Only 5ml blood needed
  • 5 day turnover
  • Performs from 9th week of pregnancy

Need consultation?
Call 0968.911884

  • 5ml

    amount of blood needed

  • 5days

    delivery of results

  • 9week

    when to have the test

  • ihope

    -25%
    8.0 6.0Million
    per sample
    • Down, Edwards, Patau
    • Other aneuploidies
    • Express service available
    • 5 day turnaround
    • 500 Million insurance
    Learn more
  • iwish

    18Million
    per sample
    • Down, Edwards, Patau
    • 5 microdeletions
    • Other aneuploidies
    • 7 day turnaround
    • 1.5 Billion insurance
    Learn more
  • ivip

    30Million
    per sample
    • Down, Edwards, Patau
    • 20 microdeletions
    • 20 skeletal mutations
    • 10 day turnaround
    • 1.5 Billion insurance
    Learn more

Who needs ihope

ihope is highly recommended to all mothers due to unmatched safety and high reliability of the test. Specifically, pregnant women who are classified to high risk group should get ihope prior to decision of conducting an aminocentesis. Mothers who should take ihope:

  • Above 30 years old, specially over 35
  • Have previous poor pregnancy
  • Have abnormal results of ultrasound screening
  • Have high-risk results of serum prenatal tests
  • Have IVF treatment
  • Have multiple baby pregnancy
  • Have any family members suffering chromosome disorder

Comparison

Popular prenatal screening methods

Method Detection Accuracy Deviation Risk Fee (VND)
Ultrasound Down
Neural tube defects
Congenital heart
N/A N/A N/A 100,000 - 500,000
Double test Down
Edwards
85-90% 10% Yes 300,000 - 1,000,000
Triple test Down
Edwards
65% 35% Yes 300,000 - 1,000,000
Invasive All chromosomes 99.99% N/A Infected amniotic fluid
Infected placenta
Premature, miscarriage,…
N/A
ihope non-invasive Down
Edwards
Patau
Sex chromosome
99.9% <0.1% Yes 6,000,000

Test procedure

  • Doctor consultation
    Step 1

  • Blood extraction
    Step 2

  • Report analysis
    Step 3

  • Delivery of reports
    Step 4

Down syndrome

Trisomy chromosome 21

Down syndrome, the most common type of chromosome abnormality, is caused by having an additional copy of chromosome 21. Chance is one out of 700 to 1000 newborns having Down syndrome (in average), hence it is necessary to perform prenatal tests for Down syndrome.

People with Down syndrome have physical malformations (facial appearance, poor muscle tone), mental retardation, and learning difficulties. With latest advances in medical science and caretaking, however, it is possible for people with Down syndrome to live for 40-50 years.

Edwards syndrome

Trisomy chromosome 18

Edwards syndrome is a chromosomal disorder caused by having an extra copy chromosome 18. It is the second most common disorder after Down Syndrome and occurs three to four times more frequently in female infants. There is one case of Edwards syndrome out of 3,000 newborn babies.

Malformations of various chromosome 18 organs and mental disorder occur, and most babies die before or immediately after birth. Half of the cases can live for one month and 10% can live more than one year. All of them need special care. Babies are often born small and have round faces, small heads, small jaws, heart defects, severe intellectual disability and clenched fists with overlapping fingers.

Patau syndrome

Trisomy chromosome 13

Patau syndrome is a chromosome abnormality of three copies of chromosome 13 instead of a pair. It is a rare disorder, one out of 25000 newborns.

Even though it is rare, Patau syndrome is a severe disorder, involving congenital malformations of various organs, especially the cerebral nervous system. In fact, only 2% survive a live birth and rarely survive beyond a few months of life.

x y

Sex chromosome disorder

Sex chromosome disorders belong to a group of genetic conditions that are caused or affected by the loss, damage or addition of sex chromosomes which leads to Klinefelter and Turner syndrome. There are major differences in lethal effects of these conditions, yet most of cases have abnormality in physical activities and mental behaviours.

Fetus gender

In compliance with Vietnamese law, NIPT results will report only the abnormal conditions of sex chromosome and NOT indicate gender of the fetus.

In other cases, written orders of doctors are required to perform genetic tests linked to sex chromosome (clearly show gender of fetuses).

FAQs

  • What is NIPT / NIPS actually?

    It is a screening test to detect fetal aneuploidy by NGS (Next Generation Sequencing) analysis of cffDNA (cell-free fetus DNA) from pregnant women’s peripheral blood. It is called NIPT / NIPS as it only needs to analyze the maternal blood sample, avoiding invasive collection of fetal samples that is necessary in cases of amniocentesis or CVS.

  • Why should I get an ihope?

    ihope can tell pregnancies with higher risk for fetal aneuploidy such as Down syndrome, Edwards syndrome, and Patau syndorme at an early stages of gestation by simply analyzing cffDNA in the maternal blood sample. Only 5ml blood is needed to perform the test which results in safety and convenience.

  • Which chromosome will be analyzed?

    Each cell of a human body (except germ cells such as oocytes or sperm cells) have 46 chromosomes, 23 inherited from each parent. If there is an extra copy of a chromosome present in the particular cell nuclei instead of the normal two, it causes developmental abnormalities. It is called a trisomy. Fetal trisomy in chromosome 21, 18, or 13 can lead to a viable birth with each of the trisomy called Down syndrome, Edwards syndrome, and Patau syndrome, respectively. Additionally, if one copy of the sex chromosomes is missing, it is call monosomy or Turner syndrome.

  • What are the symtoms?

    Trisomy of chromosome 21, 18, and 13 has different symptoms. Chromosome 21: Down syndrome, Chromosome 18: Edwards syndrome, Chromosome 13: Patau syndrome. Chromosome 23: Turner, Klinefleter, XXY syndrome.

  • Why do I need an ihope before deciding to get an amniocentesis?

    The accuracy of the present serum-based screening test is relatively low. Serum-based general screening could be regarded as convenient and non-invasive. However, the false positive rate of those serum-based screening tests may lead to the increased number of amniocentesis test, which is used as the eventual diagnostic test for high-risk pregnancies indicated by serum-based screening. Serum screening tests analyze the concentrations of a certain group of serum proteins of which level in the blood is known to be associated with the risk of fetal aneuploidy. In contrast, the ihope test can dramatically reduce the unnecessary invasive amniocentesis with its overall test accuracy above 99%, which is based on the direct analysis of fetal chromosomal DNA using cutting-edge NGS technologies. The false positive rate of the ihope test is estimated to be under 0.1%.

  • My wife was pregnant at the age of 40, therefore we decided to conduct a NIPT test which had outstanding features of unmatched safety and reliability. iDNA was our destination after a quick research and we never regretted. The delivery time was very quick, about one week with reasonable prices and after birth warranty. Our child was born healthy, which was the only thing we desired most.

    Mr. Hiếu Thuận

    TPHCM
  • NIPT tests are very popular in Singapore and every mother is recommended to perform this test at whichever ages. When having the second child and being unable to go back to Singapore, my wife decided to take this test in Vietnam. Fortunately, NIPT has been more popular in Vietnam and we could have the test with the similar fee to Singapore. My child was born safe and sound in Vietnam.

    Mr. Andrew Yap

    Singapore
  • On holding the high-risk result of Double test, I was totally shocked. It came right before Tet holidays and struck our family completely. After Tet, I contacted iDNA in Hà Nội to have consultation then carried out the NIPT test. Luckily, the result was fine, we were relieved and completely happy when our child was born healthy.

    Mrs. Mai Phương

    Hà Nội

Schedule

Schedule an appointment with us to perform a prenatal screening test. It takes only one minute to fill in the registration form.

Address

We have offices in Hồ Chí Minh, Hà Nội and Đà Nẵng. Let us have an opportunity to serve you by visiting our nearest official address.

Have questions? Call Lan now!

Lê Ngọc Lan — Head of Consult
  • 0972.899911
  • [email protected]
Prenatal screening test
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